Abstract: There is growing evidence demonstrating that the adolescent NSSI (non-suicidal self-injury) can be explained by the interaction of gene and environment.Two main theoretical models have been proposed to describe G×Es: the diathesis-stress model stipulates that genetic vulnerability predisposes an individual to the development of a psychiatric disorder when exposed to adversity,while the differential-susceptibility model proposes that individuals vary in their susceptibility to environmental influences (both negative and positive).In order to get a better understanding of gene-environment interaction of NSSI,a multilevel analysis (genetic,neuro,trait,environment and NSSI) has been proposed in this review.Future research can be focus on the positive environment G×Es and adolscent study,as well as the underlying mechanisms of gene-environment interaction.

Key words: non-suicidal self-injury, gene-environment interaction, adolescence